18.3% of ADULTS IN MALAYSIA ARE DIABETES
2.3 mil MALAYSIAN ARE HAVING DIABETES, HIGH BLOOD PRESSURE AND HIGH CHOLESTEROLS
UNDERSTANDING DIABETIC
How insulin works
Pterorcarpus Marsupium (Vijaysar)
Vijaysar is widely used in Ayurveda as a “Rasayana” (rejuvenating) herb. The bark of Vijaysar has significant importance in Ayurveda in managing diabetes and is also known as “The miracle cure for Diabetes” mainly due to its Tikta (bitter) nature.
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Vijaysar helps to manage blood sugar levels by preventing the damage to pancreatic cells and promoting insulin secretion due to its antioxidant and anti-inflammatory activity.
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Vijaysar protects the liver against cell damage caused by free radicals due to its antioxidant activity.
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Vijaysar is effective in improving heart health by decreasing the production of bad cholesterol and fatty acids and also keeps a check on body weight due to its antioxidant and anti-inflammatory properties.
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Vijaysar might be beneficial for managing diarrhea by decreasing the frequency of stools due to its antidiarrhoeal property and also helps to expel intestinal worms due to its anthelmintic activity.
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Gymnema Sylvestre (Gurmar)
Gymnema Sylvestre is a plant used in Ayurveda, an ages-old form of holistic medicine practiced in India. The plant is a perennial vine found in tropical regions of India, as well as Africa and Australia. It is also known as Australian cowplant and periploca of the woods.
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Gurmar, which is translated as "sugar destroyer." This is because gymnema leaves contain a compound called gymnemic acid that suppresses the taste of sugar.
Small studies also suggest that Gymnema Sylvestre may block sugar and fat absorption in the body, the effect of which may be useful in treating obesity, diabetes, and high cholesterol.
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Gymnema Sylvestre is said to lower sugar cravings while reducing the rate at which sugar and fat are absorbed into the body. This two-fold action may help treat obesity, diabetes, and high cholesterol.
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Gymnema Sylvestre is thought to increase insulin production by improving cell growth in the pancreas where insulin is produced.
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Gymnema Sylvestre is also thought to lower the amount of sugar that gets absorbed in the intestines. This may further help improve blood sugar levels in people with diabetes or prediabetes.
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Gymnema Sylvestre may also block the absorption of lipids (fats), thereby lowering "bad" low-density lipoprotein (LDL) levels in the blood.
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CLINICAL TEST ON PTEROCARPUS MARSUPIUM (VIJAYSAR) AND GYMNEMA SYLVESTRE (GURMAR)
RESEARCH CENTRE: CENTRE OF TRANSLATIONAL RESEARCH, JIWAJI UNIVERSITY INDIA
SUBMISSION DATE: SEPTEMBER 26, 2017
PUBLISHED DATE: AUGUST 28, 2018
RESEARCH NO: JCMAH 2018.07.555718
MIXTURE TEST: PTEROCARPUS MARSUPIUM (VIJAYSAR) AND GYMNEMA SYLVESTRE (GURMAR) - "VG"
A total of 45 type 2 diabetic patients the weekend diabetes clinic run by the Centre for Translational Research, School of Studies in Biochemistry, Jiwaji University, India expressed their willingness to participate in the study. Of these, 35 subjects met the inclusion criteria who were then explained the necessity of maintaining defined lifestyle pattern during the course of the study. Out of 35 subjects, 8 subjects were eliminated during the course of the study due to non-compliance. The remaining 27 subjects took the herb regimen regularly as per the experimental design.
Effect of VG therapy on hyper-glycemia
Table 3 shows the fasting and postprandial blood glucose levels at monthly intervals in subjects on “VG” therapy. A significant decrease was recorded for fasting (13.5% P<0.05), postprandial (15.0%, <0.001) glucose levels and glycosylated hemoglobin (9.8%) at the end of six months therapy
Effect of VG therapy on lipidemia
Table 4 shows the results of the lipid profile of patients on “VG” therapy. Total cholesterol, triglycerides, LDL and VLDL were significantly decreased after six months therapy by 9.6%, 14.4%, 15.7%, and 14.4% respectively (P<0.05). HDL cholesterol was elevated from32.50±1.11 to 35.69 ± 1.02 (P<0.001).
Effect of VG therapy on biomarkers of oxidative stress
Significant (P<0.05, P<0.001), improvements in GSH level (from 1.98±0.17 to 2.59±0.21 mg/dl), SOD activity (from 0.63±0.05 to 0.94±0.08 µM/min/mg protein), catalase activity (from 7.64±0.24 to 9.44±0.23 µM/min/mg protein) were recorded. A significant decrease (P<0.001) in TBARS (from 457.19±8.09 to 415.15±7.47 (moles of Malondialdehyde/ml of blood) were recorded at the end of six months therapy.
Effect of VG therapy on markers of toxicity
The effect of “VG” therapy on kidney function was monitored by estimating urea, uric acid and creatinine levels in plasma at specified intervals during the course of therapy. The data presented in Table 5 showed significant (P<0.05), reductions in Urea (from 29.97±1.20 to 27.10±0.88mg/dl) and uric acid (from 5.08±0.20 to 4.67±0.20 mg/dl) and notable reduction in creatinine (from 0.78±0.06 to 0.73±0.05) at the end of six months therapy. Significant (P< 0.05), variations in biochemical markers of liver functions, namely bilirubin (from 0.83±0.06 to 0.70±0.04 mg/ml) and SGOT (from 22.47±1.61 to 18.00±1.04 IU/L) as well as SGPT (from 23.60±2.32 to 19.26±1.38 IU/L), at the end of six months was observed (Table 6).
Effect of VG therapy on hypertension and body mass index
Table 7 shows variations in systolic blood pressure (from 133.70±2.59 to 129.22±2.39 mmHg), diastolic blood pressure (from 81.70±0.97 to 79.56±0.93 mmHg) and body mass index (from 25.21±0.64 to 24.22±0.60 kg/m2) at the end of the six months therapy
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Conclusion
In conclusion, the “VG” administration to type 2 diabetic patients with varying degrees of glycemia, lipidemia and oxidative stress provide an efficient alternative to conventional antidiabetic drugs when coupled with active lifestyle and dietary changes. Significant decrease in biochemical markers viz., blood glucose, HbA1c, total cholesterol, triglycerides, LDL-cholesterol, and VLDL-cholesterol and higher values of HDL, following VG therapy are testimony to the anti-diabetic efficacy of VG. Further, the formulation did not show any adverse effects on liver and kidney functions and may be a potential natural and safe therapy for treatment and prevention of diabetic complications but randomized controlled trials are required to confirm these findings.
